Prostaglandin Receptor Agonist

Prostaglandin Receptor Agonists (65):

Cat. No.	Product Name	Effect	Purity

HY-14899

Taprenepag	Agonist	98.79%
Taprenepag (CP-544326) is a potent and selective prostaglandin EP(2) agonist with IC₅₀s of 10 and 15 nM for human and rat EP2, respectively. Taprenepag shows selectivity for EP2 over other EP receptors (IC50s>3200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors.

HY-14839A

Evatanepag sodium	Agonist
Evatanepag sodium is a non-prostanoid, potent and selective EP₂ receptor agonist. Evatanepag sodium can induce local bone formation in vivo. Evatanepag sodium can be used in the research of fractures, bone defects, asthma.

HY-128686

KAG-308	Agonist	99.88%
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a K_i and an EC₅₀ of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor.

HY-106961

ONO 1301	Agonist	99.06%
ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig.

HY-108415

Cloprostenol sodium salt	Agonist	99.52%
Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist.

HY-139419

Bimatoprost grenod	Agonist	98.34%
Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma.

HY-112152

GSK726701A	Agonist	98.27%
GSK726701A is a novel prostaglandin E2 receptor 4 (EP4) partial agonist with a pEC₅₀ of 7.4.

HY-114910

11-Deoxy Prostaglandin E2	Agonist	≥99.0%
11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC₅₀ of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions.

HY-12956S

Dinoprost-d₄	Agonist	≥99.0%
Dinoprost-d₄ is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

HY-B0577S

Latanoprost-d₄	Agonist	≥98.0%
Latanoprost-d₄ is the deuterium labeled Latanoprost. Latanoprost (PHXA41) is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).

HY-114671

Taprostene	Agonist
Taprostene (CG-4203) is a synthetic, chemically stable analogue of Prostacyclin (PGI2). Taprostene exhibits endothelium and myocardial protecting actions after acute myocardial ischemia and reperfusion in cats. Taprostene enhances cytoprotective actions, while minimizing unwanted hemodynamic effects.

HY-108415R

Cloprostenol sodium salt (Standard)	Agonist
Cloprostenol sodium salt (Standard) is the analytical standard of Cloprostenol sodium salt. This product is intended for research and analytical applications. Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist.

HY-130395

15-Keto latanoprost	Agonist
15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent.

HY-100441S3

Treprostinil-d₇	Agonist
Treprostinil-d7 (UT-15-d7) is a deuterated version of Treprostinil (HY-100441). Treprostinil is a highly potent DP1 and EP2 agonist with EC50s of 0.6 nM and 6.2 nM, respectively.

HY-118190

AL 8810 methyl ester	Agonist
AL 8810 methyl ester is a prostaglandin F(2α) analog and a prostaglandin F(2α) receptor agonist. Can competitively antagonize the effects of the FP receptor agonist Fluprostenol (HY-108560). AL 8810 methyl ester has no significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines.

HY-135023

5-trans-PGE2	Agonist
5-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase). This process is involved in the growth and development of breast cancer.

HY-12956S1

Dinoprost-d₉	Agonist
Dinoprost-d₉ is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

HY-108565

BMY 45778	Agonist
BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC₅₀ = 35 nM), rabbit (IC₅₀: 136 nM) and rat (IC₅₀ : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor.

HY-107381A

(+)-Cloprostenol sodium	Agonist
(+)-Cloprostenol sodium is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.

HY-138868

17-Phenyl trinor prostaglandin E2 ethyl amide	Agonist
17-Phenyl trinor prostaglandin E2 ethyl amide (17-Phenyl trinor PGE2 ethyl amide) is a EP1 receptor agonist. 17-Phenyl trinor prostaglandin E2 ethyl amide aggravates renal dysfunction and glomerulosclerosis.

Name
Email *

	Sorry, but the email address you supplied was invalid.